Stage IV CD30+ anaplastic large cell lymphoma: Response to acitretin and interferon‐α
Identifieur interne : 002182 ( Main/Exploration ); précédent : 002181; suivant : 002183Stage IV CD30+ anaplastic large cell lymphoma: Response to acitretin and interferon‐α
Auteurs : Colin Ong [Australie] ; John Sullivan [Australie] ; Mark Hertzberg [Australie] ; Karen Stapleton [Australie]Source :
- Australasian Journal of Dermatology [ 0004-8380 ] ; 2002-08.
English descriptors
- Teeft :
- Acitretin, Alcl, Anaplastic, Arthritis rheum, Cell lymphoma, Chemotherapy, Combination therapy, Conventional chemotherapy, Cutaneous, Dermatol, Enhancement, Initial presentation, Interferon, Isotretinoin, Lesion, Lung involvement, Lymphoma, Lymphoproliferative disorders, Methotrexate, Node, Nodule, Oral acitretin, Peripheral lymphoma, Primary cutaneous, Refractory, Refractory cases, Response rate, Response rates, Retinoic, Retinoic acid, Retinoids, Rheumatoid, Rheumatoid arthritis, Signal enhancement, Skin involvement, Spontaneous remission, Standard chemotherapy, Tumour, Ulcerated nodule, Units subcutaneously.
Abstract
Retinoids and interferon (IFN)‐α induce differentiation, affect cell proliferation and alter various immune parameters. In combination, their effects may be additive or even synergistic in the treatment of malignancy. We present a 53‐year‐old woman with stage IV CD30+ anaplastic large cell lymphoma with brain, lung and skin involvement. The patient had been on methotrexate for rheumatoid arthritis. After a combination of oral acitretin 50 mg daily and IFN‐α 3 million units subcutaneously 3 times per week, the skin lesions cleared within 2 months, lung lesions by 5 months and brain leisons by 7 months. Although we cannot exclude that methotrexate played a role in the development of this lymphoma and that its withdrawal contributed to the clearance of lesions, we propose that the patient's disease responded to the combination of acitretin and IFN‐α.
Url:
DOI: 10.1046/j.1440-0960.2002.00597.x
Affiliations:
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<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acitretin</term>
<term>Alcl</term>
<term>Anaplastic</term>
<term>Arthritis rheum</term>
<term>Cell lymphoma</term>
<term>Chemotherapy</term>
<term>Combination therapy</term>
<term>Conventional chemotherapy</term>
<term>Cutaneous</term>
<term>Dermatol</term>
<term>Enhancement</term>
<term>Initial presentation</term>
<term>Interferon</term>
<term>Isotretinoin</term>
<term>Lesion</term>
<term>Lung involvement</term>
<term>Lymphoma</term>
<term>Lymphoproliferative disorders</term>
<term>Methotrexate</term>
<term>Node</term>
<term>Nodule</term>
<term>Oral acitretin</term>
<term>Peripheral lymphoma</term>
<term>Primary cutaneous</term>
<term>Refractory</term>
<term>Refractory cases</term>
<term>Response rate</term>
<term>Response rates</term>
<term>Retinoic</term>
<term>Retinoic acid</term>
<term>Retinoids</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Signal enhancement</term>
<term>Skin involvement</term>
<term>Spontaneous remission</term>
<term>Standard chemotherapy</term>
<term>Tumour</term>
<term>Ulcerated nodule</term>
<term>Units subcutaneously</term>
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<front><div type="abstract" xml:lang="en">Retinoids and interferon (IFN)‐α induce differentiation, affect cell proliferation and alter various immune parameters. In combination, their effects may be additive or even synergistic in the treatment of malignancy. We present a 53‐year‐old woman with stage IV CD30+ anaplastic large cell lymphoma with brain, lung and skin involvement. The patient had been on methotrexate for rheumatoid arthritis. After a combination of oral acitretin 50 mg daily and IFN‐α 3 million units subcutaneously 3 times per week, the skin lesions cleared within 2 months, lung lesions by 5 months and brain leisons by 7 months. Although we cannot exclude that methotrexate played a role in the development of this lymphoma and that its withdrawal contributed to the clearance of lesions, we propose that the patient's disease responded to the combination of acitretin and IFN‐α.</div>
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<name sortKey="Sullivan, John" sort="Sullivan, John" uniqKey="Sullivan J" first="John" last="Sullivan">John Sullivan</name>
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